The weekend show airs Saturdays from 3 to 6pm ET and 7 to 9pm ET, and Sundays from 5 to 8pm ET.
She succeeds Poppy Harlow, who now co-hosts CNN Newsroom weekdays.
Since joining CNN as Denver-based correspondent in 2013, Cabrera has covered high-profile stories, including the unrest in Ferguson following the shooting of Michael Brown, reported extensively on the marijuana legalization movement, and worked with the CNN Investigative team.
Before CNN, she spent four years as morning anchor for KMGH-TV 7 News, the ABC affiliate in Denver.